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Clinical Evidence of Bioavailability & Tolerability
Recent clinical studies have shown increased plasma levels as well as tolerability with GPM™ Fermented Zinc and GPM™ Fermented Iron.
In a double-blind, randomized crossover trial (Jäger et al., 2024; Nutrients), 16 adults received a single 11 mg dose of zinc as either GPM™ Fermented Zinc vs USP zinc oxide. Plasma zinc concentrations were significantly higher with GPM™ Fermented Zinc at 120, 180, and 240 minutes. Compared to zinc oxide, GPM™ Fermented Zinc demonstrated an ~40% greater incremental AUC and a ~10% higher Cmax (trend). Both formulations were well tolerated, with no reports of gastrointestinal distress.
In a randomized, three-period crossover trial (Secrest et al., 2025; Cureus), 17 adults received 18 mg of iron as GPM™ Fermented Iron vs ferrous bisglycinate (FBC) vs ferrous fumarate (FF). GPM™ Iron demonstrated superior absorption, with serum iron levels averaging +27 mcg/dL higher than FF and a significantly greater iAUC compared to both FBC and FF. All formulations were well tolerated, with no gastrointestinal side effects reported, highlighting GPM™’s favorable safety profile.
“Our fermentation process is already clinically proven to improve nutrient absorption and digestive comfort. Now, via our proprietary fermentation process, GPM™ Biome naturally generates beneficial postbiotics with clinically supported immune benefits,” said Árpád Széchényi, President & CEO of Pharmachem Innovations. “This innovation reflects consumer demand for science-driven, clean-label, solutions that support gut and microbiome health.”
GPM™ Innovations on Display @ SupplySide Global
- – GPM™ Biome Immunity Blend with Postbiotics – a ready-to-mix hydration formulation featuring a refreshing Berry Boost flavor to support immune health.
- – GPM™ Women’s Health Mix with Cran-Max™ – a Strawberry Lemonade formulation supporting urinary tract and overall women’s wellness.
- – GPM™ Magnesium Hydrate+ – a Tropical Sunset flavor designed to promote relaxation, energy metabolism, and muscle health.
- – GPM™ Multivitamin Chew – A fermented women’s daily multivitamin mix made in collaboration with FoodPharma in Cinny-Bomb flavor.
Pharmachem invites attendees to visit Booth #4845 at SupplySide Global to explore the full line of GPM™ Fermented Nutrients with postbiotics, sample new flavor innovations, and learn about the latest clinical research.
About Pharmachem Innovations
Pharmachem Innovations, a household name in the nutraceutical industry for more than 40 years, develops and manufactures science-backed ingredients and advanced nutrient delivery systems that power the next generation of dietary supplements and functional foods and beverages. With decades of manufacturing expertise and clinically studied ingredients, including proprietary platforms such as GPM™ Fermented Nutrients, Phase 2™ Carb Controller, Cran-Max™ Cranberry Concentrate, and Acti-Solve™ Engineered Delivery Systems, Pharmachem helps leading brands worldwide translate nutrition science into meaningful consumer solutions.
